Antibiotic streamlining from combination therapy to monotherapy utilizing an interdisciplinary approach

Antimicrobial Stewardship Programs
Written By Adventure Administrator
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Cases necessitating streamlining decreased from 98.6% during first month to 54.4% during seventh month. Total cost savings of $38,920.95 during intervention period. Annual cost savings estimated to be $107,637 after adjusting for changes in improved prescribing practices.

Reference:
Briceland LL, Nightingale CH, Quintiliani R, Cooper BW, Smith KS. Antibiotic Streamlining from Combination Therapy to Monotherapy Utilizing an Interdisciplinary Approach.  Archives of Internal Medicine. 1988 (148): 2019-2022

Setting:
600-bed, community teaching hospital, Hartford, CT, USA

Key staff:
infectious disease physicians, nursing-unit pharmacists

Intervention:
Streamlining – Patients on two or more empiric parenteral antibiotics identified by nursing unit pharmacist, results shared with ID physician, who then called prescribing physician to suggest alternative monotherapy.

Impact:
Cases necessitating streamlining decreased from 98.6% during first month to 54.4% during seventh month. Total cost savings of $38,920.95 during intervention period.  Annual cost savings estimated to be $107,637 after adjusting for changes in improved prescribing practices.


Adventure Administrator

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